<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e8dfd-05cc-7f4d-8938-9ef3f0bee005,g:d29e9b78-66bc-4fbc-8223-f3c5f979c36d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="akba-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e8dfd-074b-7f04-9f2a-855d534dc132" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e8dfd-074b-7c50-ae0f-92b166c31f49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e8dfd-074b-7f04-9f2a-855d534dc132" xlink:to="loc_us-gaap_Liabilities_019e8dfd-074b-7c50-ae0f-92b166c31f49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e8dfd-074b-7aef-9fb5-7bfaac5956f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e8dfd-074b-7f04-9f2a-855d534dc132" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e8dfd-074b-7aef-9fb5-7bfaac5956f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e8dfd-074b-7a43-9d8a-e1eb44c74f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e8dfd-074b-7f04-9f2a-855d534dc132" xlink:to="loc_us-gaap_StockholdersEquity_019e8dfd-074b-7a43-9d8a-e1eb44c74f8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7ce0-8f29-799c6c1b25b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e8dfd-074b-75c4-9e09-53db62a96b73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7ce0-8f29-799c6c1b25b4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e8dfd-074b-75c4-9e09-53db62a96b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e8dfd-074b-706a-80ec-1b21bd86edca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7ce0-8f29-799c6c1b25b4" xlink:to="loc_us-gaap_InventoryNet_019e8dfd-074b-706a-80ec-1b21bd86edca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e8dfd-074b-768f-9c27-8814985fad18" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7ce0-8f29-799c6c1b25b4" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e8dfd-074b-768f-9c27-8814985fad18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e8dfd-074b-7020-b1c8-ab3c7b97456f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7ce0-8f29-799c6c1b25b4" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e8dfd-074b-7020-b1c8-ab3c7b97456f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7c37-8269-dbc478cc80ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:to="loc_us-gaap_AssetsCurrent_019e8dfd-074b-7c37-8269-dbc478cc80ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e8dfd-074b-79d2-922c-082b31d7c097" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e8dfd-074b-79d2-922c-082b31d7c097" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e8dfd-074b-77ea-8425-91bc170a6042" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e8dfd-074b-77ea-8425-91bc170a6042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e8dfd-074b-7606-866f-41cf450a8e88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:to="loc_us-gaap_Goodwill_019e8dfd-074b-7606-866f-41cf450a8e88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e8dfd-074b-7595-aad1-b9ce0e7db3c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e8dfd-074b-7e80-8b72-9451431eadfe" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e8dfd-074b-7595-aad1-b9ce0e7db3c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019e8dfd-074b-769c-b3aa-3358057aaa69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:to="loc_us-gaap_PreferredStockValue_019e8dfd-074b-769c-b3aa-3358057aaa69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e8dfd-074b-7ff6-a80f-2354472efdba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:to="loc_us-gaap_CommonStockValue_019e8dfd-074b-7ff6-a80f-2354472efdba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e8dfd-074b-78b3-a0fd-b9a69703793f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e8dfd-074b-78b3-a0fd-b9a69703793f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e8dfd-074b-7214-b868-fce56792f81b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e8dfd-074b-7214-b868-fce56792f81b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e8dfd-074b-71ac-af22-57dd89f35a05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e8dfd-074b-727e-ad43-008e97b24898" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e8dfd-074b-71ac-af22-57dd89f35a05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent_019e8dfd-074b-79c7-b479-826682e1f3d7" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent_019e8dfd-074b-79c7-b479-826682e1f3d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-7e8e-9c80-2235f8c599b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-7e8e-9c80-2235f8c599b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e8dfd-074b-7843-b22f-314792c44c7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e8dfd-074b-7843-b22f-314792c44c7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityNoncurrent_019e8dfd-074b-729d-9cf1-4a2551c9c73c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityNoncurrent_019e8dfd-074b-729d-9cf1-4a2551c9c73c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e8dfd-074b-769f-8354-e7d595026796" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e8dfd-074b-769f-8354-e7d595026796" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_019e8dfd-074b-7240-9882-e3cc52e264b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilitiesNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_019e8dfd-074b-7240-9882-e3cc52e264b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent_019e8dfd-074b-7677-9aa4-d4a9cedacc65" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent_019e8dfd-074b-7677-9aa4-d4a9cedacc65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fa8de-9122-72bc-9e8d-bf4afb6f4319" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e8dfd-074b-7322-a828-424ef5c13011" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fa8de-9122-72bc-9e8d-bf4afb6f4319" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e8dfd-074b-75da-8c74-49b09c80473e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e8dfd-074b-75da-8c74-49b09c80473e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-75fc-ba04-2837bc6a1082" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-75fc-ba04-2837bc6a1082" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e8dfd-074b-7673-bfa5-e4d6a78da296" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e8dfd-074b-7673-bfa5-e4d6a78da296" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e8dfd-074b-7f1e-bf8a-7b23e5381969" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e8dfd-074b-7f1e-bf8a-7b23e5381969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019e8dfd-074b-78b5-a9d1-0b538e2e4394" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e8dfd-074b-73a9-a813-e46d9fc82974" xlink:to="loc_us-gaap_LongTermDebtCurrent_019e8dfd-074b-78b5-a9d1-0b538e2e4394" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="akba-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e8dfd-074b-732f-adf0-85e55a2eb375" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-7fc0-8919-fa39b7e842d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e8dfd-074b-732f-adf0-85e55a2eb375" xlink:to="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-7fc0-8919-fa39b7e842d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-71f1-aa46-a97b4cec6445" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-725f-99af-12319212fb98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-71f1-aa46-a97b4cec6445" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-725f-99af-12319212fb98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e8dfd-074b-7ffb-94a4-751e01cdde97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-71f1-aa46-a97b4cec6445" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e8dfd-074b-7ffb-94a4-751e01cdde97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019e8dfd-074b-7def-a8fa-73bfff4f8c89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-71f1-aa46-a97b4cec6445" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019e8dfd-074b-7def-a8fa-73bfff4f8c89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019e8dfd-074b-7450-a079-4d08a6aa0540" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-71f1-aa46-a97b4cec6445" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019e8dfd-074b-7450-a079-4d08a6aa0540" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-767f-82e8-574ffa95c19b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e8dfd-074b-7366-8347-29bb144dd287" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-767f-82e8-574ffa95c19b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e8dfd-074b-7366-8347-29bb144dd287" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-7181-a83e-d0dd2354d082" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-767f-82e8-574ffa95c19b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e8dfd-074b-7181-a83e-d0dd2354d082" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e8dfd-074b-7a8f-8cab-c230ca0f2193" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019e8dfd-074b-7f4b-8dc9-e4a1a6b814ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfRevenue_019e8dfd-074b-7a8f-8cab-c230ca0f2193" xlink:to="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019e8dfd-074b-7f4b-8dc9-e4a1a6b814ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-7d6b-be8d-904faf3091ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e8dfd-074b-7822-a278-23d1cc559d64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-7d6b-be8d-904faf3091ee" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e8dfd-074b-7822-a278-23d1cc559d64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e8dfd-074b-79fd-9225-26d77e57c8e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-7d6b-be8d-904faf3091ee" xlink:to="loc_us-gaap_CostOfRevenue_019e8dfd-074b-79fd-9225-26d77e57c8e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e8dfd-074b-754f-ae19-486772e64037" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e8dfd-074b-7d6b-be8d-904faf3091ee" xlink:to="loc_us-gaap_OperatingExpenses_019e8dfd-074b-754f-ae19-486772e64037" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e8dfd-074b-7d11-ba81-55ccf44df1d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_LicenseExpense_019e8dfd-074b-7a37-8797-1afdf1ba4b18" xlink:href="akba-20260630.xsd#akba_LicenseExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e8dfd-074b-7d11-ba81-55ccf44df1d3" xlink:to="loc_akba_LicenseExpense_019e8dfd-074b-7a37-8797-1afdf1ba4b18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e8dfd-074b-7fc0-92e8-25f5144774da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e8dfd-074b-7d11-ba81-55ccf44df1d3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e8dfd-074b-7fc0-92e8-25f5144774da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e8dfd-074b-724f-90ab-58ac5166ea7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e8dfd-074b-7d11-ba81-55ccf44df1d3" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e8dfd-074b-724f-90ab-58ac5166ea7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019ed634-a9ff-751b-8198-e0a04e456f8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e8dfd-074b-7d11-ba81-55ccf44df1d3" xlink:to="loc_us-gaap_RestructuringCharges_019ed634-a9ff-751b-8198-e0a04e456f8b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="akba-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://akebia.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e8dfd-074b-7b99-8888-2b84a29a1e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7d9d-bf8c-0639818e69ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e8dfd-074b-7b99-8888-2b84a29a1e0a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7d9d-bf8c-0639818e69ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7b2d-99b2-bf4bdd430607" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e8dfd-074b-7b99-8888-2b84a29a1e0a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7b2d-99b2-bf4bdd430607" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7b02-8daf-06bfeb66b335" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e8dfd-074b-7b99-8888-2b84a29a1e0a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7b02-8daf-06bfeb66b335" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_019e8dfd-074b-729b-84d3-a4c9cb6ccbd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_019e8dfd-074b-729b-84d3-a4c9cb6ccbd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019e8dfd-074b-7063-8dac-03d5158984ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019e8dfd-074b-7063-8dac-03d5158984ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ProceedsFromIssuanceOfCommonStockNetOfIssuanceCosts_019e8dfd-074b-7670-a6d0-07061faffd94" xlink:href="akba-20260630.xsd#akba_ProceedsFromIssuanceOfCommonStockNetOfIssuanceCosts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_akba_ProceedsFromIssuanceOfCommonStockNetOfIssuanceCosts_019e8dfd-074b-7670-a6d0-07061faffd94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019e8dfd-074b-7240-a3fa-3bae73678483" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019e8dfd-074b-7240-a3fa-3bae73678483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019e8dfd-074b-7b4d-9259-a6835423b6f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019e8dfd-074b-7b4d-9259-a6835423b6f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_RepaymentOfWorkingCapitalFundLiability_019e8dfd-074b-74ba-8216-a036d84537b3" xlink:href="akba-20260630.xsd#akba_RepaymentOfWorkingCapitalFundLiability"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_akba_RepaymentOfWorkingCapitalFundLiability_019e8dfd-074b-74ba-8216-a036d84537b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_RepaymentOfLiabilityRelatedToSettlementRoyalties_019e8dfd-074b-7489-abce-96f6cbce2014" xlink:href="akba-20260630.xsd#akba_RepaymentOfLiabilityRelatedToSettlementRoyalties"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_akba_RepaymentOfLiabilityRelatedToSettlementRoyalties_019e8dfd-074b-7489-abce-96f6cbce2014" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_019e8dfd-074b-79af-b49f-c998f0dc49cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e8dfd-074b-7e33-9be9-5ae0d1098b4d" xlink:to="loc_us-gaap_RepaymentsOfDebt_019e8dfd-074b-79af-b49f-c998f0dc49cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-71a6-977c-371b3e7f7b11" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_NetIncomeLoss_019e8dfd-074b-71a6-977c-371b3e7f7b11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019e8dfd-074b-762b-944d-74e44a52ef93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_Depreciation_019e8dfd-074b-762b-944d-74e44a52ef93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccountsReceivableCreditLossExpense_019e8dfd-074b-7af2-ab71-202e22f6ed04" xlink:href="akba-20260630.xsd#akba_AccountsReceivableCreditLossExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_akba_AccountsReceivableCreditLossExpense_019e8dfd-074b-7af2-ab71-202e22f6ed04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019e8dfd-074b-72d5-a180-97cff483e8e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019e8dfd-074b-72d5-a180-97cff483e8e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementNoncashRoyaltyRevenue_019e8dfd-074b-703c-ba86-73215598efbc" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementNoncashRoyaltyRevenue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementNoncashRoyaltyRevenue_019e8dfd-074b-703c-ba86-73215598efbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_NoncashInterestExpense_019e8dfd-074b-7ced-94f6-bb5d5e2d15e7" xlink:href="akba-20260630.xsd#akba_NoncashInterestExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_akba_NoncashInterestExpense_019e8dfd-074b-7ced-94f6-bb5d5e2d15e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StraightLineRent_019e8dfd-074b-75e5-b362-e0211e3f0fdc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StraightLineRent"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_StraightLineRent_019e8dfd-074b-75e5-b362-e0211e3f0fdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019e8dfd-074b-73fc-ba74-9a78f16c232b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_InventoryWriteDown_019e8dfd-074b-73fc-ba74-9a78f16c232b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019e8dfd-074b-786e-88a6-a527789de538" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019e8dfd-074b-786e-88a6-a527789de538" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e8dfd-074b-7f14-aa60-76eb8b8957fa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_ShareBasedCompensation_019e8dfd-074b-7f14-aa60-76eb8b8957fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e8dfd-074b-7673-bd36-8a34cca9d8b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e8dfd-074b-7673-bd36-8a34cca9d8b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e8dfd-074b-7714-92b4-7598dd317438" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e8dfd-074b-7714-92b4-7598dd317438" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e8dfd-074b-72bd-aa0e-d833926ff38f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e8dfd-074b-72bd-aa0e-d833926ff38f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e8dfd-074b-7675-a27e-b8c9e1d4c85e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e8dfd-074b-7675-a27e-b8c9e1d4c85e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e8dfd-074b-725e-a1fa-b6d1b5d55b74" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e8dfd-074b-725e-a1fa-b6d1b5d55b74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e8dfd-074b-7c9d-97f4-a3bcf3bf06e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e8dfd-074b-7c9d-97f4-a3bcf3bf06e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019e8dfd-074b-7cb4-bfed-9b970e63ee1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019e8dfd-074b-7cb4-bfed-9b970e63ee1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e8dfd-074b-77d7-b984-8ad854a32c82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e8dfd-074b-77d7-b984-8ad854a32c82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019e8dfd-074b-7045-a175-380b8a71a4c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019e8dfd-074b-7045-a175-380b8a71a4c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019f9076-6ab9-7993-a879-8da86d1f2276" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfLongLivedAssetsHeldForUse"/>
    <link:calculationArc order="20" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e8dfd-074b-7c22-a084-23e83657b146" xlink:to="loc_us-gaap_ImpairmentOfLongLivedAssetsHeldForUse_019f9076-6ab9-7993-a879-8da86d1f2276" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7a0a-bc52-ecb6377cbe4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e8dfd-074b-7843-aa01-5133a49005ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7a0a-bc52-ecb6377cbe4f" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e8dfd-074b-7843-aa01-5133a49005ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019e8dfd-074b-7e50-969d-e3b50cad2c26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7a0a-bc52-ecb6377cbe4f" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019e8dfd-074b-7e50-969d-e3b50cad2c26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019f9076-0742-7aaa-93c1-6b48c8312766" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e8dfd-074b-7a0a-bc52-ecb6377cbe4f" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019f9076-0742-7aaa-93c1-6b48c8312766" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESScheduleofReconciliationsDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESScheduleofReconciliationsDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESScheduleofReconciliationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e8dfd-074b-78f7-821d-c7b8bf6de4ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019e8dfd-074b-73a1-8887-e4bd3359ae87" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e8dfd-074b-78f7-821d-c7b8bf6de4ee" xlink:to="loc_us-gaap_RestrictedCash_019e8dfd-074b-73a1-8887-e4bd3359ae87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e8dfd-074b-72c3-9ee5-9f15d1639906" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e8dfd-074b-78f7-821d-c7b8bf6de4ee" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e8dfd-074b-72c3-9ee5-9f15d1639906" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/INVENTORIESScheduleofComponentsofInventoryDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#INVENTORIESScheduleofComponentsofInventoryDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/INVENTORIESScheduleofComponentsofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019e8dfd-074b-7c9f-8e10-5c68886931f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-73b5-855b-32d4aa6439a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNoncurrent_019e8dfd-074b-7c9f-8e10-5c68886931f9" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-73b5-855b-32d4aa6439a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e8dfd-074b-7514-8c2e-a2798352648f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNoncurrent_019e8dfd-074b-7c9f-8e10-5c68886931f9" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e8dfd-074b-7514-8c2e-a2798352648f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_InventoryNetCurrentAndNonCurrent_019e8dfd-074b-754e-a230-ff05b2e88bee" xlink:href="akba-20260630.xsd#akba_InventoryNetCurrentAndNonCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e8dfd-074b-74dc-897c-11916e8e2f15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_InventoryNetCurrentAndNonCurrent_019e8dfd-074b-754e-a230-ff05b2e88bee" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e8dfd-074b-74dc-897c-11916e8e2f15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e8dfd-074b-72ca-aefd-931575396fb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_InventoryNetCurrentAndNonCurrent_019e8dfd-074b-754e-a230-ff05b2e88bee" xlink:to="loc_us-gaap_InventoryNet_019e8dfd-074b-72ca-aefd-931575396fb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-73f4-9d19-c3df70d62868" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_InventoryNetCurrentAndNonCurrent_019e8dfd-074b-754e-a230-ff05b2e88bee" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-73f4-9d19-c3df70d62868" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e8dfd-074b-7a38-8314-38b56716a87f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-7f25-9875-85b841d644ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e8dfd-074b-7a38-8314-38b56716a87f" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e8dfd-074b-7f25-9875-85b841d644ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e8dfd-074b-7b07-bf51-39632a08f816" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e8dfd-074b-7a38-8314-38b56716a87f" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e8dfd-074b-7b07-bf51-39632a08f816" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofPrepaidsandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#ADDITIONALBALANCESHEETDETAILScheduleofPrepaidsandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofPrepaidsandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e8dfd-074b-779d-86ea-502d7b06881f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019e8dfd-074b-72ea-b882-d608e590ac4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e8dfd-074b-779d-86ea-502d7b06881f" xlink:to="loc_us-gaap_OtherAssetsCurrent_019e8dfd-074b-72ea-b882-d608e590ac4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_019e8dfd-074b-785b-b142-05bebb89175f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e8dfd-074b-779d-86ea-502d7b06881f" xlink:to="loc_us-gaap_RestrictedCashCurrent_019e8dfd-074b-785b-b142-05bebb89175f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofOtherLongTermAssetsDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#ADDITIONALBALANCESHEETDETAILScheduleofOtherLongTermAssetsDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofOtherLongTermAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e8dfd-074b-78d8-8bcd-e9682f4f6861" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019e8dfd-074b-7dcf-9b3c-8c78c4307c9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019e8dfd-074b-78d8-8bcd-e9682f4f6861" xlink:to="loc_us-gaap_InventoryNoncurrent_019e8dfd-074b-7dcf-9b3c-8c78c4307c9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_019e8dfd-074b-7047-bf23-f1b73c64e16f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsMiscellaneousNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019e8dfd-074b-78d8-8bcd-e9682f4f6861" xlink:to="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_019e8dfd-074b-7047-bf23-f1b73c64e16f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofAccruedExpensesandotherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#ADDITIONALBALANCESHEETDETAILScheduleofAccruedExpensesandotherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/ADDITIONALBALANCESHEETDETAILScheduleofAccruedExpensesandotherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedProductRevenueAllowancesExcludingRebatesCurrent_019e8dfd-074b-77b6-b3e3-326283cccaf9" xlink:href="akba-20260630.xsd#akba_AccruedProductRevenueAllowancesExcludingRebatesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedProductRevenueAllowancesExcludingRebatesCurrent_019e8dfd-074b-77b6-b3e3-326283cccaf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedProductRebatesCurrent_019e8dfd-074b-7308-a12b-eb4a23f566d6" xlink:href="akba-20260630.xsd#akba_AccruedProductRebatesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedProductRebatesCurrent_019e8dfd-074b-7308-a12b-eb4a23f566d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedProductRevenueReturnReservesCurrent_019e8dfd-074b-7a6f-9f52-8cc35dabf5a6" xlink:href="akba-20260630.xsd#akba_AccruedProductRevenueReturnReservesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedProductRevenueReturnReservesCurrent_019e8dfd-074b-7a6f-9f52-8cc35dabf5a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedClinicalExpensesCurrent_019e8dfd-074b-7c57-9ffd-98214ab385e8" xlink:href="akba-20260630.xsd#akba_AccruedClinicalExpensesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedClinicalExpensesCurrent_019e8dfd-074b-7c57-9ffd-98214ab385e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e8dfd-074b-702c-9901-1cf5a5f397ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e8dfd-074b-702c-9901-1cf5a5f397ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e8dfd-074b-755d-8dcf-4328494a5fd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e8dfd-074b-755d-8dcf-4328494a5fd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_019e8dfd-074b-7d20-acb0-8c344c28e9fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_019e8dfd-074b-7d20-acb0-8c344c28e9fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019e8dfd-074b-7dce-891a-0f9e6af88f19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019e8dfd-074b-7dce-891a-0f9e6af88f19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedManufacturingCostsCurrent_019e8dfd-074b-7ade-8d78-8aed528739ab" xlink:href="akba-20260630.xsd#akba_AccruedManufacturingCostsCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedManufacturingCostsCurrent_019e8dfd-074b-7ade-8d78-8aed528739ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent_019e8dfd-074b-79a2-891c-1b2af68f0af9" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent_019e8dfd-074b-79a2-891c-1b2af68f0af9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent_019e8dfd-074b-7433-9097-3c9fab414550" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent_019e8dfd-074b-7433-9097-3c9fab414550" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_AccruedMilestonePaymentsDueCurrent_019e8dfd-074b-76d6-aeef-d871b2a066a0" xlink:href="akba-20260630.xsd#akba_AccruedMilestonePaymentsDueCurrent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_akba_AccruedMilestonePaymentsDueCurrent_019e8dfd-074b-76d6-aeef-d871b2a066a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e8dfd-074b-793c-97b8-b84fadeaafa6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e8dfd-074b-793c-97b8-b84fadeaafa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_019ed643-5652-7900-b406-600a14ca7618" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e8dfd-074b-764c-bffd-39535cb42ead" xlink:to="loc_us-gaap_RestructuringReserveCurrent_019ed643-5652-7900-b406-600a14ca7618" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/INDEBTEDNESSScheduleofFuturePrincipalPaymentsontheTermLoansDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#INDEBTEDNESSScheduleofFuturePrincipalPaymentsontheTermLoansDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/INDEBTEDNESSScheduleofFuturePrincipalPaymentsontheTermLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-745c-bc95-a3d1dd5780d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019e8dfd-07f7-7082-9bb1-ea0b54fb2d13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-745c-bc95-a3d1dd5780d5" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019e8dfd-07f7-7082-9bb1-ea0b54fb2d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e8dfd-07f7-7e5c-bf2c-207ccc3d1721" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-745c-bc95-a3d1dd5780d5" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e8dfd-07f7-7e5c-bf2c-207ccc3d1721" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e8dfd-07f7-7eb0-96aa-884eb059fb14" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-745c-bc95-a3d1dd5780d5" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e8dfd-07f7-7eb0-96aa-884eb059fb14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e8dfd-07f7-776e-bbe3-ef03fad4e93a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-7868-ae54-13fc02574489" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e8dfd-07f7-776e-bbe3-ef03fad4e93a" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019e8dfd-07f7-7868-ae54-13fc02574489" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019e8dfd-07f7-738a-a7db-12f2c6574814" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e8dfd-07f7-776e-bbe3-ef03fad4e93a" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019e8dfd-07f7-738a-a7db-12f2c6574814" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSettlementRoyaltiesDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSettlementRoyaltiesDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSettlementRoyaltiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiability_019e8dfd-07f8-711a-980a-4983a97eea8b" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementSettlementLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent_019e8dfd-07f8-7261-b230-c7dde8e13ff4" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiability_019e8dfd-07f8-711a-980a-4983a97eea8b" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent_019e8dfd-07f8-7261-b230-c7dde8e13ff4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent_019e8dfd-07f8-77f9-826c-6df79a0024da" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiability_019e8dfd-07f8-711a-980a-4983a97eea8b" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityNoncurrent_019e8dfd-07f8-77f9-826c-6df79a0024da" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoWorkingCapitalFundsDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoWorkingCapitalFundsDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoWorkingCapitalFundsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiability_019e8dfd-07f8-7a5a-92cd-49101fa518ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityNoncurrent_019e8dfd-07f8-79c2-a0a0-8b0987b71ad0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractWithCustomerRefundLiability_019e8dfd-07f8-7a5a-92cd-49101fa518ba" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityNoncurrent_019e8dfd-07f8-79c2-a0a0-8b0987b71ad0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e8dfd-07f8-7907-8c41-9f1c5e9c3a4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerRefundLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractWithCustomerRefundLiability_019e8dfd-07f8-7a5a-92cd-49101fa518ba" xlink:to="loc_us-gaap_ContractWithCustomerRefundLiabilityCurrent_019e8dfd-07f8-7907-8c41-9f1c5e9c3a4b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSaleofFutureRoyaltiesDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSaleofFutureRoyaltiesDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/LIABILITYRELATEDTOSETTLEMENTROYALTIESWORKINGCAPITALFUNDLIABILITYANDLIABILITYRELATEDTOSALEOFFUTUREROYALTIESScheduleofLiabilityRelatedtoSaleofFutureRoyaltiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementLiability_019e8dfd-07f8-7877-941d-c413e22b8862" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent_019e8dfd-07f8-7bb2-a615-2f6da0c60135" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_ContractualArrangementRoyaltiesAgreementLiability_019e8dfd-07f8-7877-941d-c413e22b8862" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityNoncurrent_019e8dfd-07f8-7bb2-a615-2f6da0c60135" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent_019e8dfd-07f8-7ccf-94b1-2d51b242d178" xlink:href="akba-20260630.xsd#akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_akba_ContractualArrangementRoyaltiesAgreementLiability_019e8dfd-07f8-7877-941d-c413e22b8862" xlink:to="loc_akba_ContractualArrangementRoyaltiesAgreementLiabilityCurrent_019e8dfd-07f8-7ccf-94b1-2d51b242d178" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ed657-bdeb-79b3-a300-9623e7d8698f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ed657-bdeb-79b3-a300-9623e7d8698f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ed657-bdeb-718d-bb62-dd736c8327b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ed657-bdeb-718d-bb62-dd736c8327b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ed657-bdeb-7dc8-9b26-dfd21640b279" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ed657-bdeb-7dc8-9b26-dfd21640b279" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ed657-bdeb-755b-bbb3-852da32d2c4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ed657-bdeb-755b-bbb3-852da32d2c4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_akba_LesseeOperatingLeaseLiabilityToBePaidAfterYearThree_019ed657-bdeb-7d34-97ad-9eb62c74c49d" xlink:href="akba-20260630.xsd#akba_LesseeOperatingLeaseLiabilityToBePaidAfterYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ed657-bdeb-73d5-894b-4bff17678b39" xlink:to="loc_akba_LesseeOperatingLeaseLiabilityToBePaidAfterYearThree_019ed657-bdeb-7d34-97ad-9eb62c74c49d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails_1" xlink:type="simple" xlink:href="akba-20260630.xsd#LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://akebia.com/role/LEASESScheduleofFutureCommitmentsunderNonCancelableLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e8dfd-07f8-746a-8b5c-e5652597d7b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e8dfd-07f8-7e33-9873-0d3d8ac69cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e8dfd-07f8-746a-8b5c-e5652597d7b5" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e8dfd-07f8-7e33-9873-0d3d8ac69cf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e8dfd-07f8-7e7c-8450-e12bf07138c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e8dfd-07f8-746a-8b5c-e5652597d7b5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e8dfd-07f8-7e7c-8450-e12bf07138c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://akebia.com/role/NETINCOMELOSSPERSHAREScheduleofEarningsperShareDetails" xlink:type="simple" xlink:href="akba-20260630.xsd#NETINCOMELOSSPERSHAREScheduleofEarningsperShareDetails"/>
  <link:calculationLink xlink:role="http://akebia.com/role/NETINCOMELOSSPERSHAREScheduleofEarningsperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e8dfd-07f8-7e43-9283-d88b67e0629d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e8dfd-07f8-7e8b-8943-761ad64ba408" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e8dfd-07f8-7e43-9283-d88b67e0629d" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e8dfd-07f8-7e8b-8943-761ad64ba408" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e8dfd-07f8-7a91-b5e5-db20f9b98955" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e8dfd-07f8-7e43-9283-d88b67e0629d" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e8dfd-07f8-7a91-b5e5-db20f9b98955" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
