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Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2204201 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2407403 - Disclosure - Summary of Significant Accounting Policies - Reconciliation of Cash, Cash Equivalents, and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Summary of Significant Accounting Policies - Revenue and Gross Accounts Receivable By Major Customer (Details) link:presentationLink link:calculationLink link:definitionLink 2409405 - Disclosure - Summary of Significant Accounting Policies - Summary of Property and Equipment and Related Accumulated Depreciation (Details) link:presentationLink link:calculationLink link:definitionLink 2110103 - Disclosure - Product Revenue, Net link:presentationLink link:calculationLink link:definitionLink 2311302 - Disclosure - Product Revenue, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 2412406 - Disclosure - Product Revenue, Net - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2413407 - Disclosure - Product Revenue, Net - Summary of Product Revenue Allowance and Reserve Categories (Details) link:presentationLink link:calculationLink link:definitionLink 2114104 - Disclosure - License, Collaboration and Other Significant Agreements link:presentationLink link:calculationLink link:definitionLink 2315303 - Disclosure - License, Collaboration and Other Significant Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2416408 - Disclosure - License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2417409 - Disclosure - License, Collaboration and Other Significant Agreements - Deferred Revenues Balance (Details) link:presentationLink link:calculationLink link:definitionLink 2418410 - Disclosure - License, Collaboration and Other Significant Agreements - Schedule of Changes in Contract Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2419411 - Disclosure - License, Collaboration and Other Significant Agreements - Schedule of Revenue Recognized Resulting from Changes in Contract Asset and Contract Liability (Details) link:presentationLink link:calculationLink link:definitionLink 2420412 - Disclosure - License, Collaboration and Other Significant Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2121105 - 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Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 2350310 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 2451429 - Disclosure - Debt - Schedule of Future Principal Payments on the Term Loans (Details) link:presentationLink link:calculationLink link:definitionLink 2452430 - Disclosure - Debt - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2153112 - Disclosure - Warrant link:presentationLink link:calculationLink link:definitionLink 2454431 - Disclosure - Warrant - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2155113 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 2356311 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2457432 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2458433 - 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Disclosure - Employee Retirement Plan link:presentationLink link:calculationLink link:definitionLink 2472444 - Disclosure - Employee Retirement Plan - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2173116 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2374313 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 2475445 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2476446 - Disclosure - Commitments and Contingencies - Schedule of Undiscounted Minimum Rental Commitments Under Non-cancelable Leases (Details) link:presentationLink link:calculationLink link:definitionLink 2477447 - Disclosure - Commitments and Contingencies - Schedule of Undiscounted Minimum Rental Commitments Under Non-cancelable Leases and Operating Leases Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2178117 - Disclosure - Net Loss per Share link:presentationLink link:calculationLink link:definitionLink 2379314 - Disclosure - Net Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 2480448 - Disclosure - Net Loss per Share - Anti-Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 2181118 - Disclosure - Quarterly Results (unaudited) link:presentationLink link:calculationLink link:definitionLink 2382315 - Disclosure - Quarterly Results (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 2483449 - Disclosure - Quarterly Results (unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink 2184119 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 2485450 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink