Washington, D.C. 20549




Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.   )



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  Preliminary Proxy Statement
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  Definitive Proxy Statement
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  Soliciting Material under §240.14a-12


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See the reverse side of this notice to obtain proxy materials and voting instructions. *** Exercise Your Right to Vote *** Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on <mtgdate>. You are receiving this communication because you hold shares in the above named company. This is not a ballot. You cannot use this notice to vote theseshares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at or easily request a paper copy (see reverse side). We encourage you to access and review all of the important information contained in the proxy materials before voting. Meeting Information Meeting Type: <mtgtype> For holders as of: <recdate> Date: Time: <mtgtime> Location: 0000462122_1 R1.0.1.18 AKEBIA THERAPEUTICS, INC., AKEBIA THERAPEUTICS, INC. 245 FIRST STREET CAMBRIDGE, MA 02142 Annual Meeting April 09, 2020 June 05, 2020 June 05, 2020 10:00 AM EDT Akebia Therapeutics, Inc. 245 First Street Cambridge, MA 02142


Please Choose One of the Following Voting Methods Vote In Person: Many stockholder meetings have attendance requirements including, but not limited to, the possession of an attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. Vote By Internet: To vote now by Internet, go to Have the information that is printed in the box marked by the arrow available and follow the instructions. Vote By Mail: You can vote by mail by equesting a paper copy of the materials, which will include a proxy card.How To Vote Before You Vote How to Access the Proxy Materials Proxy Materials Available to VIEW or RECEIVE: How to View Online: Have the information that is printed in the box marked by the arrow (located on the following page) and visit: How to Request and Receive a PAPER or E-MAIL Copy: If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request: 1) BY INTERNET: 2) BY TELEPHONE: 1-800-579-1639 3) BY E-MAIL*: * If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow (located on the following page) in the subject line. 0000462122_2 R1.0.1.18 1. Notice & Proxy Statement 2. Annual Report Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before May 24, 2020 to facilitate timely delivery.


Voting items 0000462122_3 R1.0.1.18 The Board of Directors recommends you vote FOR the following: 1. Election of Class III Directors Nominees 01 Adrian Adams 02 Maxine Gowen, Ph.D. 03 Michael Rogers The Board of Directors recommends you vote FOR proposals 2 and 3. 2. Approval of an amendment to the company’s Ninth Amended and Restated Certificate of Incorporation to increase the number of authorized shares of common stock. 3. Approval, on an advisory basis, of the compensation of the company’s named executive officers, as described in te company’s Proxy Statement. The Board of Directors recommends you vote 1 YEAR for proposal 4. 4. Approval, on an advisory basis, of the frequency of the advisory vote on executive compensation. The Board of Directors recommends you vote FOR proposal 5. 5. Ratification of the appointment of Ernst & Young LLP as the company’sindependent registered public accounting firm for the fiscal year ending December 31, 2020. NOTE: The shares represented by this proxy when properly executed will be voted in the manner directed herein by the undersignedstockholder(s). If no direction is made, this proxy will be voted FOR the election of each director nominee in proposal 1, FOR proposal 2, FOR proposal 3, FOR proposal 5 and 1 YEAR for proposal 4. If any other matters properly come before the meeting or any adjournment or postponement thereof, the person(s) named in this proxy will vote in their discretion in accordance with applicable law or rule.