{\rtf1\deflang1033\deflangfe1033\margl720\margr720\margt360\margb360{\stylesheet{\fs20\lang1033\snext0 Normal;} {\s1\sb240\keepn{\*\pn \pnlvl1\pndec\pnprev1\pnstart1\pnsp144}\b\f0\fs30\lang1033 \sbasedon0\snext0 heading 1;} {\s2\sb200\keepn{\*\pn \pnlvl2\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs26\lang1033 \sbasedon0\snext0 heading 2;} {\s3\sb180\keepn{\*\pn \pnlvl3\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 3;} {\s4\sb160\keepn{\*\pn \pnlvl4\pnucltr\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 4;} {\s5\sb140\keepn{\*\pn \pnlvl5\pncltr\pnprev1\pnstart1\pnsp144}\b\f0\fs20\lang1033 \sbasedon0\snext0 heading 5;} {\s6\tqc\lang1033\sbasedon0\snext6 footer;} {\*\cs16 \additive\super\sbasedon10 footnote reference;} {\*\cs18 \additive\sbasedon10 page number;}} {\fonttbl{\f0\fnil Times New Roman;}{\f1\fnil Courier New}{\f2005\fnil Courier New;}{\f2010\fnil Wingdings;}{\f2020\fnil Webdings;}{\f2\fnil Arial;}{\f3\fnil Arial;}{\f4\fnil LucidaHandwriting;}{\f5\fnil Symbol;}{\f6\fnil Symbol;}{\f7\fnil Ferdsch;}{\f30\fnil Myriad Cn Semibold;}{\f31\fnil Myriad Roman;}{\f50\fnil Courier New;}{\f51\fnil Times New Roman;}{\f52\fnil Arial;}{\f53\fnil Symbol;}{\f54\fnil Wingdings;}{\f55\fnil Wingdings 2;}{\f56\fnil Wingdings 3;}{\f57\fnil Webdings;}{\f58\fnil Arial Narrow;}{\f59\fnil Arial Unicode MS;}{\f60\fnil Cyberbit;}{\f61\fnil Morningstar 1U Light;}{\f62\fnil Calibri;}} {\colortbl;\red0\green0\blue0;\red127\green0\blue0;\red0\green0\blue255;\red127\green127\blue127;\red0\green51\blue153;\red255\green204\blue0;\red255\green255\blue255;\red246\green244\blue236;\red0\green0\blue0;} {\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1} \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 8/31/18 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Securities and Exchange Commission \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 450 Fifth Street NW \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Washington, DC 20549 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql RE: Schedule 13G \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Akebia Theraputics inc \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql As of 8/31/2018 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Gentlemen: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql In accordance with Section 13(d)(5) of the Securities Exchange \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Act of 1934, attached please find a copy of Schedule 13G for \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql the above named company showing beneficial ownership change \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql as of 8/31/18 filed on behalf of Eagle Asset Management, \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Inc. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Very truly yours, \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Damian Sousa \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Vice President \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Chief Compliance Officer \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql DS:CC \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Enclosures \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql cc: Office of the Corporate Secretary \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Akebia Therapeutics, Inc. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 245 First Street \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Suite 1100 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Cambridge, MA 02142 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql SECURITIES AND EXCHANGE COMMISSION \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Washington, D.C. 20549 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Schedule 13G \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Under the Securities Exchange Act of 1934 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Amendment No. 3 )* \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Akebia Therapeutics, Inc. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Name of Issuer) \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Common Stock \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Title of Class of Securities) \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 00972D105 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (CUSIP Number) \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Check the following box if a fee is being paid with this statement \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql _____. (A fee is not required only if the filing person: (1) has \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql a previous statement on file reporting beneficial ownership of more \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql than five percent of the class of securities described in Item 1; \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql and (2) has filed no amendment subsequent thereto reporting beneficial \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql ownership of five percent or less of such class.) (See Rule 13d-7.) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql *The remainder of this cover page shall be filled out for a reporting \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql person's initial filing on this form with respect to the subject class \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql of securities, and for any subsequent amendment containing information \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql which would alter the disclosures provided in a prior cover page. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql The information required in the remainder of this cover page shall not \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql be deemed to be "filed" for the purpose of Section 18 of the Securities \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql that section of the Act but shall be subject to all other provisions of \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql the Act (however, see the Notes). \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Page 1 of 5 Pages \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql CUSIP NO. 00972D105 13G \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 1 NAME OF REPORTING PERSON \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Eagle Asset Management, Inc. 59-2385219 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (A) ______ \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (B) ______ \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 3 SEC USE ONLY \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 4 CITIZENSHIP OR PLACE OF ORGANIZATION \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql State of Florida \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql NUMBER OF 5 SOLE VOTING POWER \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql SHARES 0 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql BENEFICIALLY 6 SHARED VOTING POWER \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql OWNED - - - \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql AS OF \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 8/31/18 7 SOLE DISPOSITIVE POWER \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql BY EACH 0 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql REPORTING 8 SHARED DISPOSITIVE POWER \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql PERSON WITH - - - \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 0 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql [_____] \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 0% \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 12 TYPE OF REPORTING PERSON* \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql IA \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Page 2 of 5 Pages \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 1(a) Name of Issuer: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Akebia Therapeutics Inc. \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 1(b) Address of Issuer's Principal Executing Offices: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Akebia Therapeutics, Inc. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 245 First Street \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Suite 1100 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Cambridge, MA 02142 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(a) Name of Person Filing: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Eagle Asset Management, Inc. \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(b) Address of Principal Business Office: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 880 Carillon Parkway \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql St. Petersburg, Florida 33716 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(c) Citizenship: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Florida \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(d) Title of Class of Securities: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Common Stock \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(e) CUSIP Number: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 00972D105 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 3 Type of Reporting Person: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (e) Investment Adviser registered under Section 203 of the Investment \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Advisors Act of 1940 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Page 3 of 5 Pages \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 4 Ownership as of 08/31/18 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (a) Amount Beneficially Owned: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 0 shares of common stock beneficially owned including: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql No. of Shares \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Eagle Asset Management, Inc. 0 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (b) Percent of Class: 0% \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (c) Deemed Voting Power and Disposition Power: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (i) (ii) (iii) (iv) \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Deemed Deemed \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Deemed Deemed to have to have \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql to have to have Sole Power Shared Power \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Sole Power Shared Power to Dispose to Dispose \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql to Vote or to Vote or or to or to \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql to Direct to Direct Direct the Direct the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql to Vote to Vote Disposition Disposition \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Eagle Asset 0 ---- 0 ---- \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Management, Inc. \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 5 Ownership of Five Percent or Less of a Class: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql If this statement is being filed to report the fact that \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql as of the date here of the reporting person has ceased to be the beneficial \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql owner of more than five percent of the class of securities, check the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql following. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql ( X) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 6 Ownership of More than Five Percent on Behalf of Another Person: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql N/A \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 7 Identification and Classification of the Subsidiary which Acquired \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql the Security Being Reported on by the Parent Holding Company: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql N/A \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Page 4 of 5 Pages \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 8 Identification and Classification of Members of the Group: N/A \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 9 Notice of Dissolution of Group: N/A \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 10 Certification: \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql By signing below I certify that to the best of my \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql knowledge and belief, the securities referred to above were acquired \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql in the ordinary course of business and were not acquired for purpose of \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql and do not have the effect of changing or influencing the control of \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql the issuer of such securities and were not acquired in connection with \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql or as a participant in any transaction having such purposes or effect. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Signature \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql After reasonable inquiry and to the best of my knowledge \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql and belief, I certify that the information set forth in this statement is \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql true, complete and correct. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Date: 8/31/18 EAGLE ASSET MANAGEMENT, INC. \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql _________________________________ \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Damian Sousa \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Vice President \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Chief Compliance Officer \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Page 5 of 5 Pages \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16}