аЯрЁБс>ўџ ўџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџ l ЩсСПРт\pThe Free Software Foundation Bфœ=PF0*8X@"Зк1Д Helvetica1ДCourier1Д Courier New1ДМ Courier New1Д Helvetica$#,##0_);($#,##0)$#,##0_);[Red]($#,##0)$#,##0.00_);($#,##0.00)$#,##0.00_);[Red]($#,##0.00)-**_($* #,##0_);_($* (#,##0);_($* "-"_);_(@_)*)'_(* #,##0_);_(* (#,##0);_(* "-"_);_(@_)5,2_($* #,##0.00_);_($* (#,##0.00);_($* "-"??_);_(@_)2+/_(* #,##0.00_);_(* (#,##0.00);_(* "-"??_);_(@_)2$#,##0.00;[Red]$#,##0.003$#,##0.00;[Red]($#,##0.00)4$#,##0;[Red]($#,##00)50.00%;[Red](0.00%)6 0%;[Red](0%)7#,##0.00;[Red](#,##0.00)8#,##0;[Red](#,##0)рѕџ Р рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР рѕџ єР р Р р+ѕџ јР р)ѕџ јР р,ѕџ јР р*ѕџ јР р ѕџ јР р аˆ ~~Пр иˆ ~~Пр#иˆ ~~Пр7#мˆ ~~Пр иˆ ~~Пр"иˆ ~~Пр8#мˆ ~~П“€џ“€џ“€џ“€џ“€џ“€џ’т8џџџџџџџџџџџџ€€€€€€€€€РРР€€€™™џ™3fџџЬЬџџffџ€€fЬЬЬџ€џџџџџџ€€€€€џЬџЬџџЬџЬџџ™™Ьџџ™ЬЬ™џџЬ™3fџ3ЬЬ™ЬџЬџ™џfff™–––3f3™f333™3™3f33™ЧЧЧ… February 2 2018…SFebruary 2 2018 (1)…\1February 2 2018 (2) l Щ 9>р  dќЉёвMbP?_*+‚€%џРŒ,Сƒ„&Тй­e2й?'Тй­e2й?(Тй­e2й?)Тй­e2й?Ё",D/р?р?фFebruary 2 2018 (1)February 2 2018 (2)U } † } $ } $} $ } Ж 9ссссссссс с с с с сссссссссссссссссссNovo Holdings A/SSC 13G 02/13/2018February 2, 2018~  ! Name of Reporting Person:     1 )Novo Holdings A/S (formerly known as Novo   A/S)~   0 (Check the Appropriate Box if a Member of!Group (See Instructions): (a) ? (b) ?~  SEC Use Only:~ -%Citizenship or Place of Organization:Denmark Number of~ Sole Voting Power:Shares B eneficially~ тs— O wned B y E ach R eporting~ Shared Voting Power:P ersonW ith:~ ~ Sole Dispositive Power:зDlуџбџЛџЏџ“џ‡џ{џoџџмўИўkўCўѕ§И§‡§c§0§ §СќќyќNќѕћГћhћQћ@ћфњЁњ с!с"с#с$с%с&с'с(с)с*с+с,с-с.с/с0с1с2с3с4с5с6с7с8с       !!!!!!~ !тs—""""~ """!"Shared Dispositive Power:#######$$$$$$~ $~ %&%.%&Aggregate Amount Beneficially Owned by&&&Each Reporting Person:'''((~ (тs—~ )*):)2Check if the Aggregate Amount in Row (11) Excludes***Certain Shares:+++,, ,?~ -.-.-&Percent of Class Represented By Amount... In Row (11):///000 5.25% (1)~ 121!1Type of Reporting Person:22233 3CO45$6____________________________17)Created by Morningstar Document Research.08(http://documentresearch.morningstar.com/з6ZрЌџVџчў“ў=ўё§З§“§m§§тќОќ™ќMќќљћЬћћiћCћ7ћ+ћћ=PF0*8X> Ж@хњ887766331100..--,,**))((&&%%     l Щ ?А&Ѕ0  dќЉёвMbP?_*+‚€%џРŒ,Сƒ„&Тй­e2й?'Тй­e2й?(Тй­e2й?)Тй­e2й?Ё",D/р?р?фFebruary 2 2018February 2 2018 (2)U } I } $ } †} $ } y< ?ссссссссс с с с с сссссссссссссссссссNovo Holdings A/SSC 13G 02/13/2018February 2, 2018 Item 1.  (a)  Name of Issuer:       $ Akebia Pharmaceuticals, Inc.      (b) / 'Address of Issuer?s Principal ExecutiveOffices:$245 First Street, Suite 1100Cambridge, MA 02142Item 2. (a)Name of Person Filing:5-Novo Holdings A/S, a Danish limited liability0(company, is wholly owned by Novo Nordisk80Fonden (the ? Foundation ?), a Danish commercial4,foundation. Novo Holdings A/S is the holding91company in the group of Novo companies (currently0(comprised of Novo Nordisk A/S, Novozymes0(A/S and NNIT A/S) and is responsible for3+managing the Foundation?s assets, including5-its financial assets. Based on the governance:2structure of Novo Holdings A/S and the Foundation,0(the Foundation is not deemed to have anyзDг lуџбџЛџЏџ“џ‡џ{џoџ3џоўКўbў>ўи§”§p§§ЩќЅќIќ%ќМћXћьњ„њњГљOљшјј с!с"с#с$с%с&с'с(с)с*с+с,с-с.с/с0с1с2с3с4с5с6с7с8с9с:с;с<с=с>с    . &beneficial ownership of the securities!!!!0!(of the Issuer held by Novo Holdings A/S."""## #(b)#0#(Address or Principal Business Office or,$$$$$if none, Residence:%%%&&&&&Tuborg Havnevej 19'''''2900 Hellerup, Denmark((()) )(c))-)%Citizenship or Place of Organization:***++++"+Novo Holdings A/S: Denmark,,,-- -(d)-%-Title of Class of Securities:...///// Common Stock00011 1(e)11 CUSIP Number:22233333 00972D 10 5445Item 3.5=55If this statement is filed pursuant to ??240.13d-1(b)6616)or 240.13d-2(b) or (c), check whether the777person filing is a:88899999Not applicable.:;$<____________________________1=)Created by Morningstar Document Research.0>(http://documentresearch.morningstar.com/зB­ Xžџ:џџЏў`ў<ўю§œ§x§§№ќšќvќќіћЎћŠћ>ћћгњЛњ[њњзљГљhљ\љPљ(љ=PF0*8X> Ж@х2>>==<<776655 l Щ y:  dќЉёвMbP?_*+‚€%џРŒ,Сƒ„&Тй­e2й?'Тй­e2й?(Тй­e2й?)Тй­e2й?Ё",D/р?р?фFebruary 2 2018February 2 2018 (1)U } †6} $ } y} U ссссссссс с с с с ссссссссссссссссссNovo Holdings A/SSC 13G 02/13/2018February 2, 2018  & (a) Amount beneficially owned:  ~ тs—~ ўџџџ   (b)???Percent of class:   @ % (2)  /'(c)???Number of shares as to which such person has:5-(i) Sole power to vote or to direct the vote:~ тs—~ ўџџџ2*(ii) Shared power to vote or to direct the~  vote:0((iii) Sole power to dispose or to direct~ тs—~ ўџџџthe disposition of:1)(iv) Shared power to dispose or to direct~ the disposition of:$____________________________1)Created by Morningstar Document Research.0(http://documentresearch.morningstar.com/зBЇXуџбџЛџЏџ“џ‡џ{џoџ3џџНўЅўGў/ўЬ§Е§§0§§АќŸќ‡ќќќшћћbћVћ.ћ=PF0*8X> Ж@х Root Entryџџџџџџџџ РFўџџџBook џџџџџџџџџџџџ ; ўџџџўџџџ§џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџ