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EXHIBIT INDEX…2EX44 Exhibit 44…Ÿ8EX45 Exhibit 45…Д>Signature page follows l Щ P  dќЉёвMbP?_*+‚€%џРŒ,Сƒ„&Тй­e2й?'Тй­e2й?(Тй­e2й?)Тй­e2й?Ё",D/р?р?ф800 Boylston Street!CALCULATION OF REGISTRATION FEE EXHIBIT INDEXEX44 Exhibit 44EX45 Exhibit 45Signature page followsU } ’0} $ } ’ ссссссссс с с с с сссссссс!Akebia Therapeutics, Inc. S-8 01/26/2018!AKEBIA THERAPEUTICS, INC. Delaware   20-8756903' (State or other jurisdiction of  (I.R.S. Employer& incorporation or organization)  Identification No.)  0 (245 First Street, Suite 1100, Cambridge, ~ z! 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S-8 01/26/2018 EXHIBIT INDEX Exhibit   Description No.   ffffff@ . &Ninth Amended and Restated Certificate  - %of Incorporation (previously filed as1)Exhibit 3.1 to the current report on Form808-K filed on March 28, 2014 (File No. 001-36352).&and incorporated herein by reference).ЭЬЬЬЬЬ@0(Amended and Restated By-laws (previously2*filed as Exhibit 3.2 to the current report1)on Form 8-K filed on March 28, 2014 (File.&No. 001-36352) and incorporated hereinby reference).333333@-%2014 Incentive Plan (previously filed2*as Exhibit 10.29 to Amendment No. 1 to the0(Registration Statement on Form S-1 (File2*No. 333-193969) filed on March 4, 2014 and*"incorporated herein by reference).š™™™™™@6.Form of Officer Inducement Award Non-Statutory0(Stock Option Agreement (filed herewith).зDъlлџЬџЖџЊџ‘џ…џyџmџIџџџьўœўSўўВ§h§P§ўќАќcќќчћЯћ€ћ2ћцњ˜њRњ:њ с!с"с#с$с%с&с'с(с)с*с+с,с-с.с/с0с1с2с  !@!.!&Form of Inducement Award Non-Statutory""0"(Stock Option Agreement (filed herewith).##$ffffff@$5$-Opinion of Ropes & Gray LLP (filed herewith).%%&š™™™™7@&6&.Consent of Ernst & Young LLP (filed herewith).''(3333337@(0((Consent of Ropes & Gray LLP (included in))*)"the opinion filed as Exhibit 5.1).**+š™™™™8@+4+,Power of attorney (included on the signature,,1,)page of this Registration Statement under--)-!the caption ?Power of Attorney?)../$0____________________________11)Created by Morningstar Document Research.02(http://documentresearch.morningstar.com/з*hhшџ˜џLџ4џнўХўmўUўўН§Ѕ§O§§НќБќЅќ}ќ=PF0*8X> Ж@х221100 l Щ 8  dќЉёвMbP?_*+‚€%џРŒ,Сƒ„&Тй­e2й?'Тй­e2й?(Тй­e2й?)Тй­e2й?Ё",D/р?р?фAKEBIA THERAPEUTICS INC800 Boylston Street!CALCULATION OF REGISTRATION FEE EXHIBIT INDEXEX45 Exhibit 45Signature page followsU } U5} $ } Ж ссссссссс с с с с ссссс!Akebia Therapeutics, Inc. 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