{\rtf1\deflang1033\deflangfe1033\margl720\margr720\margt360\margb360{\stylesheet{\fs20\lang1033\snext0 Normal;} {\s1\sb240\keepn{\*\pn \pnlvl1\pndec\pnprev1\pnstart1\pnsp144}\b\f0\fs30\lang1033 \sbasedon0\snext0 heading 1;} {\s2\sb200\keepn{\*\pn \pnlvl2\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs26\lang1033 \sbasedon0\snext0 heading 2;} {\s3\sb180\keepn{\*\pn \pnlvl3\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 3;} {\s4\sb160\keepn{\*\pn \pnlvl4\pnucltr\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 4;} {\s5\sb140\keepn{\*\pn \pnlvl5\pncltr\pnprev1\pnstart1\pnsp144}\b\f0\fs20\lang1033 \sbasedon0\snext0 heading 5;} {\s6\tqc\lang1033\sbasedon0\snext6 footer;} {\*\cs16 \additive\super\sbasedon10 footnote reference;} {\*\cs18 \additive\sbasedon10 page number;}} {\fonttbl{\f0\fnil Times New Roman;}{\f1\fnil Courier New}{\f2005\fnil Courier New;}{\f2010\fnil Wingdings;}{\f2020\fnil Webdings;}{\f2\fnil Arial;}{\f3\fnil Arial;}{\f4\fnil LucidaHandwriting;}{\f5\fnil Symbol;}{\f6\fnil Symbol;}{\f7\fnil Ferdsch;}{\f30\fnil Myriad Cn Semibold;}{\f31\fnil Myriad Roman;}{\f50\fnil Courier New;}{\f51\fnil Times New Roman;}{\f52\fnil Arial;}{\f53\fnil Symbol;}{\f54\fnil Wingdings;}{\f55\fnil Wingdings 2;}{\f56\fnil Wingdings 3;}{\f57\fnil Webdings;}{\f58\fnil Arial Narrow;}{\f59\fnil Arial Unicode MS;}{\f60\fnil Cyberbit;}{\f61\fnil Morningstar 1U Light;}{\f62\fnil Calibri;}} {\colortbl;\red0\green0\blue0;\red127\green0\blue0;\red0\green0\blue255;\red127\green127\blue127;\red0\green51\blue153;\red255\green204\blue0;\red255\green255\blue255;\red246\green244\blue236;\red0\green0\blue0;\red153\green153\blue153;} {\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1}\par\pard\plain\brdrb\brdrs\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\ql \~\par\pard\plain\sb88\cf1\f51\fs36\b\qc UNITED STATES\par\pard\plain\cf1\f51\fs36\b\qc SECURITIES AND EXCHANGE COMMISSION\par\pard\plain\cf1\f51\fs24\b\qc Washington, D.C. 20549\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs36\b\qc FORM\~8-K\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs24\b\qc CURRENT REPORT\par\pard\plain\cf1\f51\fs24\b\qc PURSUANT TO SECTION\~13 OR 15(D)\par\pard\plain\cf1\f51\fs24\b\qc OF THE SECURITIES EXCHANGE ACT OF 1934\par\pard\plain\sb264\cf1\f51\fs24\b\qc Date of Report (Date of earliest event reported): April\~9, 2018\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs48\b\qc AKEBIA THERAPEUTICS, INC.\par\pard\plain\cf1\f51\fs20\b\qc (Exact name of registrant as specified in its charter)\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs24\ql \~ \par\pard\plain {\trowd\clvertalc\cellx3671\clvertalb\cellx3779\clvertalc\cellx7235\clvertalb\cellx7342\clvertalc\cellx10800\trrh66 \pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{ {\trowd\clvertalc\cellx3671\clvertalb\cellx3779\clvertalc\cellx7235\clvertalb\cellx7342\clvertalc\cellx10800\trrh66\row}}} {\trowd\cellx3671\clvertalb\cellx3779\cellx7235\clvertalb\cellx7342\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\b\qc Delaware\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\qc 001-36352\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\qc 20-8756903\cell{ {\trowd\cellx3671\clvertalb\cellx3779\cellx7235\clvertalb\cellx7342\cellx10800\trrh248\row}}} {\trowd\cellx3671\clvertalb\cellx3779\cellx7235\clvertalb\cellx7342\cellx10800\trrh418 \pard\plain\intbl\cf1\f51\fs16\b\qc (State or other jurisdiction\par\pard\plain\intbl\sa22\cf1\f51\fs16\b\qc of incorporation)\cell\pard\plain\intbl\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (Commission\par\pard\plain\intbl\sa22\cf1\f51\fs16\b\qc File Number)\cell\pard\plain\intbl\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (IRS Employer\par\pard\plain\intbl\sa22\cf1\f51\fs16\b\qc Identification No.)\cell{ {\trowd\cellx3671\clvertalb\cellx3779\cellx7235\clvertalb\cellx7342\cellx10800\trrh418\row}}}\pard\plain\cf1\f51\fs24\ql \~ \par\pard\plain {\trowd\clvertalc\cellx5436\clvertalb\cellx5580\clvertalc\cellx10800\trrh66 \pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{ {\trowd\clvertalc\cellx5436\clvertalb\cellx5580\clvertalc\cellx10800\trrh66\row}}} {\trowd\cellx5436\clvertalb\cellx5580\clvertalb\cellx10800\trrh518 \pard\plain\intbl\cf1\f51\fs20\b\qc 245 First Street\par\pard\plain\intbl\sa22\cf1\f51\fs20\b\qc Cambridge, Massachusetts\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\b\qc 02142\cell{ {\trowd\cellx5436\clvertalb\cellx5580\clvertalb\cellx10800\trrh518\row}}} {\trowd\cellx5436\clvertalb\cellx5580\cellx10800\trrh198 \pard\plain\intbl\cf1\f51\fs16\b\qc (Address of Principal Executive Offices)\cell\pard\plain\intbl\cf1\f51\fs16\ql \~\cell\pard\plain\intbl\cf1\f51\fs16\b\qc (Zip Code)\cell{ {\trowd\cellx5436\clvertalb\cellx5580\cellx10800\trrh198\row}}}\pard\plain\sb264\cf1\f51\fs20\b\qc Registrant\u8217?s telephone number, including area code:\~(617) 871-2098\par\pard\plain\sb264\cf1\f51\fs20\b\qc 245 First Street\par\pard\plain\cf1\f51\fs20\b\qc Suite 1100\par\pard\plain\cf1\f51\fs20\b\qc Cambridge, Massachusetts 02142\par\pard\plain\cf1\f51\fs16\b\qc (Former name or former address, if changed since last report)\par\pard\plain\cf1\f51\fs24\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\qc \~\par\pard\plain\sb264\cf1\f51\fs20\ql Check the appropriate box below if the Form\~8-K filing is intended to simultaneously satisfy the filing obligation of the\plain\cf1\f51\fs20\ql registrant under any of the following provisions:\par\pard\plain\cf1\f51\fs12\ql \~ \par\pard\plain {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\ql Written communications pursuant to Rule\~425 under the Securities Act (17 CFR 230.425)\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~ \par\pard\plain {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\ql Soliciting material pursuant to Rule\~14a-12 under the Exchange Act (17 CFR 240.14a-12)\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~ \par\pard\plain {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\ql Pre-commencement communications pursuant to Rule\~14d-2(b)\~under the Exchange Act (17 CFR 240.14d-2(b))\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs12\ql \~ \par\pard\plain {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\ql Pre-commencement communications pursuant to Rule\~13e-4(c)\~under the Exchange Act (17 CFR 240.13e-4(c))\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}}\pard\plain\sb264\fi462\cf1\f51\fs20\ql Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act\plain\cf1\f51\fs20\ql of 1933 (\u167?230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (\u167?240.12b-2 of this\plain\cf1\f51\fs20\ql chapter).\par\pard\plain\sb132\fi462\cf1\f51\fs20\ql Emerging growth company\~\~\u9746?\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition\plain\cf1\f51\fs20\ql period for complying with any new or revised financial accounting standards provided pursuant to Section\~13(a) of the Exchange\plain\cf1\f51\fs20\ql Act.\~\~\u9746?\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\cf1\f51\fs20\ql \~\par\pard\plain\brdrb\brdrs\sa44\cf1\f51\fs20\ql \~ \page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par{\*\bkmkstart part_1_2_1}{\*\bkmkend part_1_2_1}{\*\bkmkstart item_1_26_1}{\*\bkmkend item_1_26_1}\par\pard\plain\cf1\f51\fs20\b\ql Item\~1.01 Entry into a Material Definitive Agreement.\par\pard\plain\sb132\cf1\f51\fs20\ql On April\~9, 2018, Akebia Therapeutics, Inc. (the \u8220?Company\u8221?) executed the Fifth Amendment to Lease (the\plain\cf1\f51\fs20\ql \u8220?Fifth Amendment\u8221?) with CLPF-Cambridge Science Center, LLC (the \u8220?Landlord\u8221?), amending the\plain\cf1\f51\fs20\ql lease dated December\~3, 2013, by and between the Company and the Landlord, as amended (the \u8220?Lease\u8221?), for the\plain\cf1\f51\fs20\ql Company\u8217?s headquarters located at 245 First Street, Cambridge, Massachusetts (the \u8220?Building\u8221?).\par\pard\plain\sb264\cf1\f51\fs20\ql Pursuant to the Fifth Amendment, the Company has agreed to lease an additional 19,805 square feet of office space on the 12\plain\cf1\f51\fs18\ql\super th\plain\cf1\f51\fs20\ql floor of the Building (\u8220?Additional Premises\u8221?). The term of the Fifth Amendment is expected to commence on the\plain\cf1\f51\fs20\ql date the Landlord delivers the Additional Premises to the Company, or approximately September\~1, 2018 (\u8220?12\plain\cf1\f51\fs18\ql\super th\plain\cf1\f51\fs20\ql Floor\plain\cf1\f51\fs20\ql Commencement Date\u8221?), and the term expires on September\~11, 2026, subject to an option to extend the term for an\plain\cf1\f51\fs20\ql additional five years.\par\pard\plain\sb264\cf1\f51\fs20\ql The Company is obligated to pay rent for the Additional Premises beginning five months after the 12\plain\cf1\f51\fs18\ql\super th\plain\cf1\f51\fs20\ql Floor Commencement\plain\cf1\f51\fs20\ql Date (the \u8220?Rent Commencement Date\u8221?). From the Rent Commencement Date until August\~31, 2019, the monthly\plain\cf1\f51\fs20\ql rent payment will be $135,334.17 or $82.00 per square foot per year, with an annual rent escalation of $1.00 per square foot\plain\cf1\f51\fs20\ql commencing on September\~1, 2019. The Fifth Amendment includes a Landlord\u8217?s contribution for leasehold improvements\plain\cf1\f51\fs20\ql for the premises in an amount of up to $990,250.00.\par\pard\plain\sb264\cf1\f51\fs20\ql The foregoing description of the Fifth Amendment does not purport to be complete and is qualified in its entirety by reference to\plain\cf1\f51\fs20\ql the text of the Fifth Amendment, which will be filed as an exhibit to the Company\u8217?s Quarterly Report on Form 10-Q for\plain\cf1\f51\fs20\ql the quarterly period ended June\~30, 2018.\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 2 \page\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par{\*\bkmkstart part_1_2_2}{\*\bkmkend part_1_2_2}\par\pard\plain\cf1\f51\fs20\b\qc SIGNATURE\par\pard\plain\sb264\fi462\cf1\f51\fs20\ql Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed\plain\cf1\f51\fs20\ql on its behalf by the undersigned hereunto duly authorized.\par\pard\plain\cf1\f51\fs24\ql \~ \par\pard\plain {\trowd\clvertalc\cellx728\clvertalb\cellx1456\clvertalc\cellx4320\trrh66 \pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell\pard\plain\intbl\f0\fs16\ql \~\cell{ {\trowd\clvertalc\cellx728\clvertalb\cellx1456\clvertalc\cellx4320\trrh66\row}}} {\trowd\cellx4320\trrh248 \pard\plain\intbl\cf1\f51\fs20\b\ql AKEBIA THERAPEUTICS,\~INC.\cell{ {\trowd\cellx4320\trrh248\row}}} {\trowd\clvertalc\cellx4320\trrh66 \pard\plain\intbl\f0\fs16\ql \~\cell{ {\trowd\clvertalc\cellx4320\trrh66\row}}} {\trowd\clbrdrb\brdrs\brdrcf1\cellx4320\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql /s/ John P. Butler\cell{ {\trowd\clbrdrb\brdrs\brdrcf1\cellx4320\trrh248\row}}} {\trowd\clvertalb\cellx728\clvertalb\cellx1456\clvertalb\cellx4320\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql Name:\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql John P. Butler\cell{ {\trowd\clvertalb\cellx728\clvertalb\cellx1456\clvertalb\cellx4320\trrh248\row}}} {\trowd\clvertalb\cellx728\clvertalb\cellx1456\clvertalb\cellx4320\trrh495 \pard\plain\intbl\cf1\f51\fs20\ql Title:\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql President and Chief Executive\plain\intbl\cf1\f51\fs20\ql Officer\cell{ {\trowd\clvertalb\cellx728\clvertalb\cellx1456\clvertalb\cellx4320\trrh495\row}}}\pard\plain\sb264\cf1\f51\fs20\ql Date: April\~12, 2018\par\pard\plain\cf1\f51\fs16\ql \~\par\pard\plain\cf1\f51\fs20\qc 3}