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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 S-1MEF

Registration of up to an additional 20% of securities for any offering registered on an S-1

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 3

Initial filing by director officer or owner of more than ten percent.

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March 19, 2014 EFFECT

EFFECT

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Akebia Therapeutics, Inc.
245 First Street, Suite 1400
Cambridge, MA 02142

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